KetArtis

Ketoprofen belongs to the most well-studied and safe NSAIDs. In order to reduce adverse reactions, its dosage forms for topical use, including patches, have been developed.

KetArtis ® patch, due to the penetration of ketoprofen into the underlying tissues, provides an anti-inflammatory and analgesic effect at the application site, eliminating pain syndrome and reducing swelling associated with the inflammatory process.

The effectiveness of the ketoprofen patch in the framework of clinical studies exceeded that of the ketoprofen gel even when used in lower doses and with a lower frequency of administration¹, which made it possible to recommend it for the treatment of patients with inflammatory pain, for example, with osteoarthritis² and rheumatoid arthritis³.

In a comparative study with diclofenac gel, ketoprofen patch provided a higher cure rate (64% vs 46%/, p = 0.004) on day 7 in patients with benign soft tissue lesions caused by sports exercises⁴.

A review of studies of the ketoprofen patch showed that with the transdermal route of administration, the drug creates the highest concentrations in the tissues adjacent to the application site, which remain there for a long time⁵.

Composition per patch: ketoprofen – 30 mg.

Description: rectangular patches with rounded edges, consisting of a base made of non-woven material (polyester).

The size of the patch: 70 x 100 mm (70 cm²).

Pharmacodynamics

Ketoprofen in the form of a transdermal patch has a local analgesic and anti-inflammatory (including decongestant) effect. With articular syndrome, it causes a weakening of joint pain at rest and during movement, a decrease in "morning stiffness".

Pharmacokinetics

When applied topically, ketoprofen is absorbed extremely slowly, while its concentration in the blood plasma is very low, and in the adjacent affected tissues is sufficient to reduce pain and inflammation.

Indications for use

Symptomatic therapy (reduction of pain and inflammation at the time of use, does not affect the progression of the disease) in the following conditions:

• Back pain in inflammatory and degenerative diseases of the spine (sciatica, osteoarthritis, lumbago, sciatica);

• Joint pain (finger joints, knee joints, etc.) in osteoarthritis;

• Muscle pain (due to sprains, overstrain, bruises, injuries);

• Inflammation and swelling of soft tissues and joints due to injuries and rheumatic diseases (tendovaginitis, bursitis, lesions of periarticular tissues).

It is not recommended to use the patch in children under the age of 18 (efficacy and safety have not been studied).

Method of administration and dosage

Externally in the form of applications on the skin.

The patch is glued to the skin over the painful area 2 times a day.

Do not apply the patch to the damaged skin surface. Do not use for more than 14 days, the duration of therapy depends on the severity and nature of the damage. You can not apply several patches at the same time.

If there is no improvement in the condition after 7 days and if the state of health worsens, it is necessary to consult a doctor.

Release form

Transdermal patch, 30 mg.

7 patches each in a thermally welded aluminum foil bag.

Expiration date

3 years.

Vacation conditions

They are released without a prescription.

KetArtis® patch is manufactured in the Republic of Korea.

1. Komatsu T, Sakurada T. Comparison of the efficacy and skin permeability of topical NSAID preparations used in Europe. Eur J Pharm Sci. 2012 Dec 18;47(5):890-5.

2. Derry S, Conaghan P, Da Silva JA, Wiffen PJ, Moore RA. Topical NSAIDs for chronic musculoskeletal pain in adults. Cochrane Database Syst Rev. 2016 Apr 22;4:CD007400.

3. Kawai S, Uchida E, Kondo M, Ohno S, Obata J, Nawata Y, Sugimoto K, Oribe M, Nagaya I. Efficacy and safety of ketoprofen patch in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled study. J Clin Pharmacol. 2010 Oct;50(10):1171-9.

4. Esparza F, Cobián C, Jiménez JF, et al. Topical ketoprofen TDS patch versus diclofenac gel: efficacy and tolerability in benign sport related soft-tissue injuries. Br J Sports Med. 2007 Mar;41(3):134-9.

5. Mazières B. Topical ketoprofen patch. Drugs R D. 2005;6(6):337-44.

Instructions for the medical use of KetArtis® RU LP-007505 from 19.10.2021.